The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.
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The name “satellite” minissatellite to the early observation that centrifugation of genomic DNA in a test tube separates a prominent layer of bulk DNA from accompanying “satellite” layers of repetitive DNA. A novel human nonviral retroposon derived from an endogenous retrovirus. Please add a reason or a talk parameter to this template to explain the issue with the article.
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WikiProject Genetics may be able to help recruit an expert. Somatic changes are suggested to result from replication difficulties which might include replication slippageamong other phenomena. Minisatellites consist of repetitive, generally GC -rich, [ citation needed ] motifs that range in length from 10 to over base pairs. You must accept the terms and conditions. You have entered an invalid code.
Receive exclusive offers and updates from Oxford Academic. Studies have revealed distinct mutation processes operating in somatic and germline cells. Minisatellites are small sequences of DNA that do not encode proteins but appear throughout the genome hundreds of times, with many repeated copies lying next to each other. Your comment will be reviewed and published at the journal’s discretion. Email alerts New issue alert.
Views Read Edit View history. This article may be confusing or unclear to readers. Dynamic evolution of megasatellites in yeasts. They are generally non-coding DNA but sometimes are part of possible genes.
It has been proposed that minisatellite sequences encourage chromosomes to swap DNA. We present DNA sequences flanking cloned hypervariable human minisatellites. This article is also available for rental through DeepDyve. Abstract We present DNA sequences flanking cloned hypervariable human minisatellites.
Citing articles via Web of Science More on this topic A novel tRNA variable number tandem repeat at human chromosome 1q This article needs attention from an expert in Genetics. Sign in via your Institution Sign in.
When shorter 10—bp tandem repeats were later identified, they came to be known as minisatellites. Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion patterns of variant repeats along the array, which provides details on the structure of the alleles before and after mutation.
Please help improve it or discuss these issues on the talk page. The human telomere sequence itself is a tandem repeat: Emery’s Elements of Medical Genetics, 12th. Retrieved from ” https: I agree to the terms and conditions. In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements.
Add comment Close comment form modal. Minisatellites have been implicated [ citation needed ] as regulators of gene expression e. Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage.
Hypervariable ‘minisatellite’ regions in human DNA.
Such an event would ultimately lead to the extinction of a hypermutable minisatellite reegions meiotic drive. These findings have suggested gypervariable minisatellites most probably evolved as bystanders of localized meiotic recombination hotspots in the human genome.
We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function.
July Learn how and when to remove this template message. In alternative models, it is the presence of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat copy number variations. Sequences flanking the repeat arrays of human minlsatellites: