Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. matrix tablets by using Eudragit RSPO and natural gums like guar copal as rate The use of synthetic Eudragit RSPO and gum copal were unable to retard the. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.
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Sustained release formulation that would maintain plasma level for h might be sufficient for daily dosing of metformin. The composition of various formulations of the tablets with their codes is listed in Table 1.
However, the mixtures were continued to be sonicated at different time frames and were left to stir overnight to aid size reduction and to evaporate solvent present. The quadratic model of zeta potential is shown in where, and represent ratio of a polymer to a drug, concentration of a surfactant, and sonication time, respectively, and and are interaction effects between ratio of a polymer to a drug and sonication time and concentration of a surfactant and sonication time while are quadratic effect.
Fitting the in vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release. View at Google Scholar M.
Any terms in the models with high -value and small value indicate more significant effect on the respective response variables. Hausner’s ratio was related to interparticle friction and could be used to predict powder flow properties. The in vitro drug release studies were carried out in dissolution media pH 7.
Many researchers investigated various natural, semi-synthetic and synthetic polymeric materials. From equation, it was observed that ratio of a polymer and concentration of a surfactant had positive effect on mean particle size whereas sonication time had negative effect.
Click here to view all the property values for this datasheet as they were originally entered into MatWeb. It is a solid substance in form of white powder with a faint amine-like odour.
The same profile was observed in Figure 3 b.
All other ingredients used throughout the study were of analytical grade and were used as received. Modification of the traditional method with the use of surfactants improves the EE. Factors with values that are less than 0. Infrared spectrum was taken by scanning the samples of pure drug and the polymers individually over a wave number range of to cm —1 using Fourier transform infrared spectrophotometer FT-IR, Shimadzu S, Shimadzu, Japan.
All the tablets were stored in airtight containers for further study. Tenofovir was encapsulated in Eudragit RS PO in this study intended for oral administration since most studies are based on the prevention of HIV transmission [ 13 ].
The 3D surface plots illustrating the effects of independent variables on mean particle size, EE, average zeta potential, and PDI are shown in Figures 2 — 5respectively. It was applied to determine the significance and the magnitude of the effects of the main variable and their interactions by applying probability value value.
The encapsulated drug was calculated using. Matrix systems are widely used in oral controlled drug delivery because of their flexibility, cost effectiveness, low influence of the physiological variables on its release behavior and broad regulatory acceptance [ 67 ].
Time-controlled Drug release
This indicates that the drug is compatible with the polymers used in the investigation. All other chemicals used were of analytical grade and purchased from Sigma-Aldrich South Wudragit. Long term release of the drug may be due to the charge interactions between the cationic polymer and anionic drug resulting in a gradual drug release. Figure 5 in vitro cumulative release of metformin.
In order to compare the release profile of different formulas with possible difference in release mechanisms n valuesa mean dissolution time MDT [ 14 ] was calculated using Eq. Just before compression, the surfaces of the die and punches were lubricated with magnesium stearate. Nanoparticles present significant advantages over conventional free drug rzpo [ 56 ].
Materials and Methods 2. Nanoprecipitation of hydrophobic drugs is more facile than the hydrophilic ones. The optimized formulation was characterized for in vitro drug release and structural characterization.
This was further supported by the lower compressibility index. View at Google Scholar L. Compression was carried out using 14 mm flat faced circular punches into tablets on an eight station rotary press tablet compression machine Rimek Minipress I Ahmadabad, India at a eudraglt compression eucragit.
Eudragit RSPO | Gum Copal | Gum Damar | Matrix Tablets | Release Kinetics
The release profiles for both pH 7. Hydrophilic eudragit when combined with hydrophobic GC and GD FX-FXV no burst release was observed, which may be due to the tendency to mask these quaternary ammonium groups to some extent, thereby modifying release of the drug. Results of the present study demonstrated that combination of both synthetic hydrophilic Eudragit RSPO with natural hydrophobic polymers GC and CD could be successfully employed for formulating sustainedrelease matrix tablets.
The tablets were prepared by wet granulation method. View at Google Scholar W. Combining Eudragit with gum Copal and gum Damar sustained the drug release for more than 12 h. The objective of present study was to develop an optimized polymeric nanoparticle system for the antiretroviral drug tenofovir.
This can further be seen from 3D surface plots in Figure 3. It was also found that the interaction between ratio of a polymer and sonication time and concentration of surfactant and sonication time significantly influence zeta potential.
Metformin hydrochloride is an orally administered biguanide, which is widely used in the management of type-II diabetes, a common disease that combines defects of both insulin secretion and insulin action [ 1 ]. No significant change in the appearance of characteristic peaks of pure drug spectra was observed fig.
Or if you don’t have an account with us yet, then click here to register. Tenofovir nanoparticles were prepared using modified nanoprecipitation method [ 24 ] in accordance with BBD Table 2. Angle of repose was determined by funnel method. They were then coated with gold under an argon atmosphere using a gold sputter in a high vacuum evaporator.