The electroretinogram (ERG) is a diagnostic test that measures the . The multifocal ERG (mfERG) simultaneously measures local retinal. Multifocal electroretinography (mfERG) is an objective, noninvasive examination for the assessment of visual function. It enables the stimulation. Abstract. AIMS To describe the topography of multifocal electroretinograms ( ERGs) and to explore its diagnostic value in patients with Stargardt’s macular.

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Enroll in the International Ophthalmologists contest. The bipolar-cell depolarization increases the level of extracellular potassium, subsequently generating a transretinal current. However, there are many patients in whom the disease presents atypically with an absence of visible flecks and relatively spared central vision. Caused by a mutation in the ABCA gene, recessive Stargardt’s disease is one of the most common inherited conditions. The produces multiple ERG recordings reflecting the retinal response of each of the corresponding stimulated area.

Reduced a- and b-wave amplitudes in both scotopic and photopic conditions; increased rod and cone b-wave eoectrorretinograma times. The ERG can provide important diagnostic information on a variety of retinal disorders including, but not limited to congenital stationary night blindness, Leber congenital amaurosis, and cancer-associated retinopathy.

Using a cross-correlationtechnique, the software determines the electrical response of each of mulitfocal in the posterior pole. Degree of retinal toxicity related to certain drugs such as hydroxychloroquine or ethambutol is better detected using mfERG compared to ffERG.

Reduced scotopic amplitudes which improve to normal values after longer variable perior of dark adaptation. Scotopic rod responses are isolated by dark-adaptation for a minimum of 20 minutes per ISCEV standards followed by a short wavelength stimulus as a single flash or 10 Hz flicker. An example of an mfERG measurement taken from a patient with significant upper left visual field loss is shown in figure 1 superimposed onto the Humphrey visual field.


Maximal response ERG waveform from a dark adapted eye. The enhanced spatial resolution enables electdorretinograma and retinal dysfunction to be mapped and quantified. A variety of techniques have been described in the literature for recording fERGs.

In contrast to flash ERG, which best generates data appropriate for whole-eye disorders. Residents and Fellows contest rules International Ophthalmologists contest rules. Ground electrode may be placed any location on body.

This leads to closure of the sodium ion channels resulting in a decrease electrodretinograma inwardly directed sodium ions, or a hyperpolarization of the cell.

Multifocal electroretinograms are a mathematical average of an approximation of a b-wave. Additionally, this research will provide a firm foundation for comparison with pathologic changes that occur in the retina. Organize your dilating drops, balanced salt solution, topical anesthetic and cleaning products so that they are readily accessible.

If the recording electrode contacts the eye numb the eye with several drops of a topical anesthetic. For ease of pattern recognition, the software then generates a3-D waveform of the response density reflecting a much higher response in the normal foveal center.

A sink is convenient to wash your hands and to clean electrodes. Only mydriatic dilation is necessary. Unable to load video. A year-old asymptomatic female with an eight-year history of hydroxychloroquine use at 7. The central hexagons are smaller than those in the periphery. KumarHema L.

The Multifocal Electroretinogram | Vision Science and Advanced Retinal Imaging Laboratory

The electroretinogram ERG is a recording of the bioelectric potential, the summed activity of the retinal cells located at the back of the eye, when stimulated by light. In other projects Wikimedia Commons. Selective reduction in b-wave amplitude more prominent in scotopic than photopic responses; delayed photopic and scotopic b-wave implicit times.


Research Our main focus is to investigate the normal age-related changes in multifocal ERG responses and to find out and quantify the electrorretinogrmaa optical and neural factors contributing to those age-related changes see recent publications.

This precision helps correlate electrophysiologic findings with visual field testing. Please recommend JoVE to your librarian.

VSRI: Vision Research and Advanced Retinal Imaging Laboratory, University of California, Davis

Retinal trauma producing field defects produce abnormal mfERGs, consistent with visual field loss 5. For example, some retinal diseases affect the implicit response times of the photoreceptors at varying stages of progression, depending on the type of disease.

An unexpected error occurred. In late stages of the disease, full-field ERG may be nonrecordable even in the presence of a demonstrable field by kinetic perimetry.

Focal ERG is useful for assessing macular function in conditions such as electrorrwtinograma macular degeneration, however requires good fixation from the subject. To make it easier for the person being tested, the recording is divided into short segments of 15 to 30 seconds.

Photopic cone responses can be obtained either before or after dark-adaptation.


Examples of further methods and developments in mfERG signal analyses can be found in references 1, 2, 6, 7, 8. Phacoemulsification Cataract surgery Capsulorhexis. In the protocol below, we describe the recording electrorretihograma mfERGs using a bipolar speculum contact lens. A limitation of traditional full-field electroretinograms ERG for the diagnosis of retinopathy is lack of sensitivity.

Implications for the Treatment of Chronic Conditions …. Enroll in the Residents and Fellows contest.