Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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Implications of the review for practice and research Practice: The effects of endemic fluoride poisoning on the intellectual development of children in Baotou.

Chin J Public Health. Neurotoxicity of sodium fluoride in rats. We conducted sensitivity analyses restricted to studies using the same outcome assessment and having drinking-water fluoride as the only exposure.

Fluoride released into the ground water in China in some cases greatly exceeded levels that are typical in the U.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – Semantic Scholar

Beijing University Press; The diversity across the included studies and the substantial potential for bias due to meta-analydis by unidentified factors meant that the results of this review may not be reliable. In many rural communities in China, populations heurotoxicity high exposure to fluoride in local drinking-water sources may reside in close proximity to populations without high exposure NRC For concerns on copyright infringement please see: Water woo Biology Documents.

The average IQ scores was lower in children from high-fluoride and -iodine area than those from the reference area, but the results were not significant. Fluoride exposure reduced intelligence test scores in the meta-analysis SMD Future research should formally evaluate dose—response relations based on individual-level measures of exposure over time, including more precise prenatal exposure assessment and more extensive standardized measures of neurobehavioral performance, in addition to improving assessment and control of potential confounders.


By clicking accept or deveopmental to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset Teview. Wechsler Children Intelligence Scale. Misclassification of children in both high- and low-exposure groups may have occurred if the children were drinking water from other sources e. Our literature search identified 39 studies, among which 36 We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development.

However, most deficiencies relate to the reporting of where key information was missing. Operating characteristics of a rank correlation revview for publication bias.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

We did not find conclusive evidence of publication bias, although there was substantial heterogeneity among studies. In regard to the outcomes, the inverse association persisted between studies using different intelligence tests, although most studies did not report age adjustment of the cognitive test scores.

There was no evidence of publication debelopmental. Chinese researchers took advantage of this fact and published their annd, though mainly in Chinese journals and according to the standards of science at the time.

The authors call for future research to include more precise data on the children involved and greater confidence that other factors have been ruled out as contributing to differences in IQ test scores. The latter showed that dose-related deficits were found, but the studies were excluded because our meta-analysis focused on studies with the high- and low-exposure groups only.

Although microbiologically safe, water supplies from small springs or mountain sources created pockets of increased exposures near or within areas of low exposures, thus representing exposure settings close to the ideal, because only the fluoride exposure would differ between nearby neighborhoods.


Children in the high-fluoride group scored significantly lower than those in reference group. Occupational fluorosis through 50 years: Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children’s intelligence in endemic fluorosis area in Tianjin, China. In addition, two studies were published twice, and the duplicates were excluded. Analysis of water quality from homemade wells in Leshan downtown during — Average IQ of children in high-fluorosis area was lower than that in the reference area.

Estimates of effect were converted into standardised mean differences SMD and pooled develoopmental Mantel-Haenszel fixed-effect and DerSimonian-Laird random-effects meta-analyses. Funding No external funding. We also searched the China National Knowledge Infrastructure CNKI database, because many studies on fluoride neurotoxicity have been published in Chinese journals only. On the other hand, neither can it be concluded that no risk is present.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

As with anything, the dose makes the poison. The fact that some aspects of the study were not reported limits the extent to which the available reports allow a firm conclusion.

Community Dent Oral Epidem. I 2 residual However, results of the published studies have not been widely disseminated.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – RationalWiki

Future research should include detailed individual-level information on prenatal exposure, neurobehavioral performance, and covariates for adjustment. Bio Trace Elem Res. A suitable search was performed which included a relevant Chinese database.

Showing of 76 extracted citations. We searched records for —