For Injection: Teflaro is supplied as mg or mg of sterile ceftaroline fosamil powder in single-dose, 20 mL clear glass. There is minimal potential for drug-drug interactions between TEFLARO and CYP substrates, inhibitors, or inducers; drugs known to undergo active renal . To reduce the development of drug-resistant bacteria and maintain the effectiveness of TEFLARO and other antibacterial drugs, TEFLARO should be used to.
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Clostridium difficile colitis see section 4. Following administration throughout pregnancy and lactation in the rat, there was no effect on pup birth weight or growth, although minor changes in foetal weight and delayed ossification of the interparietal bone were observed when ceftaroline fosamil was administered during insrt see section 5.
Other important toxicologic findings noted in the rat and monkey included histopathologic changes in the inseert and spleen. Arrived in ED with deep and extensive cellulitis on right leg. Sign Up Log In Cancel.
When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. Marketing authorisation holder ceftatoline. Ceftaroline or ceftaroline fosamil are not metabolised by CYP enzymes in vitrotherefore co-administered CYP inducers or inhibitors are unlikely to influence the pharmacokinetics of ceftaroline.
Appropriate specimens for microbiological examination should be obtained in order to isolate and identify the causative pathogens and to determine inser susceptibility to ceftaroline. CrCL should be closely monitored and the dose adjusted according to changing renal function.
The following adverse reactions have been identified during clinical trials and post-marketing experience with Zinforo.
Zinforo 600 mg powder for concentrate for solution for infusion
Accessed August 11, There is no experience with ceftaroline in the treatment of CAP in the following patient groups: The powder must be reconstituted with water for injections and the resulting concentrate must then be immediately diluted prior to use.
Reasons for being admitted to the hospital through the emergency department, Store in the original package in order to protect from light. Apckage with other antibacterial agents In vitro studies have not demonstrated any antagonism between ceftaroline in combination with other commonly used antibacterial agents e.
Hypersensitivity to the cephalosporin class of antibacterials. Clinical study experience with ceftaroline fosamil in patients with pre-existing seizure disorders is very limited.
TEFLARO® (ceftaroline fosamil) Dosing Information
ESRD, including haemodialysis b. The development of a positive direct antiglobulin test DAGT may occur during treatment with cephalosporins.
Fertility The effects of ceftaroline nisert on fertility on humans have not been studied. Clinical efficacy has not been established against the following pathogens although in vitro studies suggest that they would be susceptible to ceftaroline in the absence of acquired mechanisms of resistance:.
Renal changes were not reversible but were reduced in severity following a 4 week recovery period. Date of first authorisation: Serious and occasionally fatal hypersensitivity reactions are possible see sections 4.
Arrived in ED with an abscess due to a suspected spider bite on her left leg. Genetic toxicology Ceftaroline fosamil and ceftaroline were clastogenic in an in vitro chromosomal aberration assay, however there was no evidence of mutagenic activity in an Ames test, mouse lymphoma and unscheduled DNA synthesis assay.
Continue typing to refine. Pregnancy There are no or limited amount of data from the use of ceftaroline fosamil in pregnant women.
Susceptibility data should be considered in conjunction with clinical trial data also presented on this website. In pooled human liver microsomes, metabolic turnover was low for imsert, indicating that ceftaroline is not metabolised by hepatic CYP enzymes. If you are a patient, and have any questions, please discuss them with your doctor or healthcare professional. For the full list of excipients, see section 6. In vitro results do not necessarily correlate with how the antibiotic will work in people.