Learn about BYETTA, the BYETTA Pen. Important Safety Information for BYETTA (exenatide) injection. Contraindications. BYETTA is contraindicated in. Exenatide (Byetta) is the first in a new class of incretin peptide mimetics .. Available at ; accessed October 15, 3. Meneilly. Exenatide (marketed as Byetta, Bydureon) is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) medication, belonging to the group of incretin.
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You can ask your healthcare provider or pharmacist for information about Byetta that is written for health professionals.
Official BYETTA® (exenatide) injection Healthcare Professional Website
Based on postmarketing data Byetta has been associated with acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis. With Metformin and a Sulfonylurea 30 Weeks. Caution should be exercised when Byetta is administered to a nursing woman. Inject Byetta into your abdomen, thigh, or upper arm using the injection method explained to you by your healthcare provider.
Go to Healthcare Professional Site. Each dose should be administered as a subcutaneous SC injection in the thigh, abdomen, or upper arm. Baseline HbA 1C across all treatment groups was 8. However, in subjects with end-stage renal disease receiving dialysis, mean exenatide exposure increased by 3. Based on three week placebo-controlled clinical trials 6 — 8.
If you cannot turn the dose knob away from you to thesee Commonly Asked Questions, number 7, in Section 4 of this user manual. This article has been cited by other articles in PMC. The amino acid sequence for exenatide is shown below. Do not share your Byetta Pen with other people, even if the needle has been changed.
To view content sources and attributions, please refer to our editorial policy. In combination with a sulfonylurea alone Buse et al evaluated exenatide versus sulfonylurea mono-therapy in a multicenter, randomized, triple-blinded, placebo-controlled study 7.
Kendall et al evaluated the effects of exenatide compared with metformin and a sulfonylurea for treatment of type 2 diabetes in a multicenter, randomized, double-blinded, placebo-controlled trial 8. Subscribe to receive email notifications whenever new articles are published.
Add BYETTA to insulin glargine as a complementary action to help improve glycemic control
Byetta should be initiated at 5 mcg administered twice daily BID at any time within the minute period before the morning and evening meals or before the two main meals of the day, approximately 6 hours or more apart.
Based on postmarketing data BYETTA has been associated with acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis. Byetta did not significantly alter the pharmacodynamic properties e.
It is not known if having these conditions will lead to a higher chance of getting pancreatitis while taking Byetta. Melanin concentrating hormone Antagonists: Therefore, the use of exenatide is not recommended in patients with severe gyetta disease 2. BYETTA slows gastric emptying and can reduce the extent and rate of absorption of orally administered drugs.
In patients taking warfarin, prothrombin time should be monitored more frequently after initiation or alteration of Byetta therapy. Safety and effectiveness of Byetta have not been established in pediatric patients. Do not throw away.
Also of interest is the preservation of the gyetta cells of the pancreas and the conversion of non—insulin-secreting cells to insulin-secreting cells in vitro.
If you hear a click sound from your Byetta Pen, ignore it.
Go to Patient Site. Exenatide was not mutagenic or clastogenic, with or without metabolic activation, in the Ames bacterial mutagenicity assay or chromosomal aberration assay in Li hamster ovary cells.
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Once a stable prothrombin time has been documented, prothrombin times can be monitored at the intervals usually recommended for patients on warfarin. Patients should be informed of the potential risks and benefits of Byetta and of alternative modes of therapy. It is important that you use your pen correctly.