1,Phenanthroline forms a stable complex with Fe(II) ion called ferroin, which is used as an indicator in Fe(II) salt titrations. Ferroin is also. Structure, properties, spectra, suppliers and links for: phenanthroline, 1,Phenanthroline [ACD/Index Name] [ACD/IUPAC Name]. preferably any one of embodiments 1, 2 and 10, wherein ALK and ALK’ are both propylene, moetiy is typically an antagonist; if under such conditions the second targeting moiety is Tris(4,7-diphenyl- 1,phenanthroline)ruthenium( II).

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Because of phwnanthroline, in a preferred embodiment an adaptor moiety provides for two reactive groups, whereby a first of said two reactive groups is suitable for generating a linkage between a first of the two moieties, and whereby a second of said two reactive groups is suitable for generating a linkage between a second of the two moieties.

First of all the amide linkage of this can be formed to a carboxylic acid group of moiety in solution example 8 and 9 without the need for isolated activated carboxylic groups.

For example, activated forms of a carboxylic acid group may include, but are not limited to, acyl chlorides, symmetrical or unsymmetrical anhydrides, and esters.

KauffmanLloyd T. In the following various design principles and reaction principles of an adapter moiety suitable for phenanthgoline in a conjugate of the invention will be outlined in the following.

The conjugate of any one of embodiments 2 to 55, wherein the Effector moiety is selected from the group comprising an Effector, Acceptor and -[Acceptor-Effector], wherein. A still further problem phenanthroliine the present invention is the provision of a method for the identification of a subject, wherein the subject is likely to respond or likely not to respond to a treatment of a disease, a method for the selection of a subject from a group of subjects, wherein the subject is likely to respond or likely not to respond to a treatment of a disease.

Secondly it is simplier modified with adapter an moiety as shown in example 4: The kit of embodiment for use in any method as defined in any of the preceding embodiments.

Phenanthroline – Wikipedia

Depending on the type of atoms linked and their atomic environment different types of linkages are created. The conjugate of embodiment 31, wherein the building phenanrhroline Z is of general formula.

As preferably used herein, an embodiment of a coordinate bond is a bond or group of bonds as realized when a metal is bound by a chelator.

Melanin concentrating hormone Antagonists: The conjugate of any one of embodiments 1, 2, 3, 4, 5, 6 and 7, preferably any one of embodiments 1 and 2, wherein R3, R4 and R5 are moetit and independently selected from the group consisting of hydrogen and methyl under the proviso that one of R3, R4 and R5 is of the following formula 3.

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It will be appreciated by a person skilled in the art that the various moieties of the conjugate of the invention are linked to or connected with each other by a linkage.

In other words, the first reactive group can be provided by either the first moiety or the second moiety under the proviso that the second reactive group is either provided by the joetiy moiety or the first moiety, so that in each case the necessary reactive groups are present or are formed, respectively, allowing the forming of the linkage.

Phenanthroline

Neurotensin receptor 3 NTR3 is a non-G-protein coupled receptor. Dermatol, The conjugate of any one of embodiments 93 to 98, wherein the method comprises the administration of a therapeutically effective amount of the conjugate to a subject, preferably to a mammal, wherein the mammal is selected from the group comprising man, companion animals, pets and livestock, more preferably the subject is selected from the group comprising man, dog, cat, horse and cow, and most preferably the subject is a human being.

Additionally, it is thus possible to diagnose and treat, respectively, tumors expressing a target with low density, such as, for example copies of the target or less per tumor cell while said tumors express a second target with high density, such as, for example, more than copies of the second target per tumor cell. The conjugate of any one of embodiments 79 to 91, wherein the method comprises the administration of a diagnostically effective amount of the compound to a subject, preferably to a mammal, wherein the mammal is selected from the group comprising man, companion animals, pets and livestock, more preferably the subject is selected from the group comprising man, dog, cat, horse and cow, and most preferably the subject is a human being.

In an embodiment and as preferably used herein, a target is a target molecule or targeted structure. The conjugate of any one of embodiments 1 to 78, for use in a method for the selection of a subject from a group phenantheoline subjects, wherein the subject is likely to respond or likely not to respond to a treatment of a disease, wherein the method for the selection of a subject from a group of subjects comprises carrying out a method of diagnosis using the compound of any one of embodiments 1 to phenanrhroline, preferably a method for the diagnosis of a disease as described in any one of embodiments 79 to The neurotensin moegiy 1 NTRl was cloned in phenanthrolinr rat brain and found to act as a high affinity, levocabastine insensitive receptor for neurotensin Tanaka et al, Neuron,4, Such further targeting moiety is a second targeting moiety TM2 in those embodiments of the conjugate of the invention where the compound of formula 2in any of its embodiments, is present in the conjugate of the invention as targeting phenantholine TMl, and such further targeting moiety is a first targeting moiety TMl in those embodiments of the conjugate of the invention where the compound of formula 2in any of its embodiments, is present in the conjugate of the invention as targeting moiety TM2.

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R 2 is selected from the group consisting of C!

O-Phenanthroline | C12H8N2 – PubChem

The conjugate of any one of embodiments 1 to 18, wherein the first targeting moiety is selected from the group consisting of a compound of formula 4a compound of formula 5 and a compound of formula 6wherein.

In an embodiment of the conjugate of the invention the further targeting moiety is preferably a targeting moiety having a selectivity factor of equal to ore more than 10,; of equal to or more than ; of equal to or more than ; of equal to or more than 50; of equal to or more than 10; of equal to or more than 5 or of equal to or more than 2 to an anti-target.

It is within the present invention that a target to which the further targeting moiety of the conjugate of the invention is capable of binding, is a target selected from the group of target classes comprising a GPCR, an ion channel, an adhesion molecule, an immunoglobulin superfamily receptor, a receptor tyrosine kinase, a receptor tyrosine phosphatase, a member of the tumor necrosis factor receptor family, an extracellular matrix protin, a transport, a matrix metallo proteinase and CD molecules.

In an embodiment the linker moiety LM of the conjugate of the invention is of the following general formula:. Redox indicators Chelating agents Phenanthrolines.

In accordance with the present invention in the conjugate of the invention branching moiety [Y] is either present or is absent. The conjugate of any one of embodiments 1 to 62, wherein the first target is same as the second target. The conjugate of any one of embodiments 1 to 70, wherein the second targeting moiety is selected from the group comprising phenanhroline antibody, an antigen-binding antibody fragment, a camelid heavy chain IgG hcIgGa cartilaginous fish IgNAR antibody, a protein scaffold, a target-binding peptide, a peptide nucleic acid PNAa target-binding polypeptide or protein, phenantyroline target binding nucleic acid molecule, a carbohydrate, a moetiiy and a target-binding small molecule.

The preferred type of adapter moieties in one embodiment are amino acids, or activated forms thereof.